Anti-LAMP3 antibody (Alexa-fluor 647)

The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.

• Clonality: Monoclonal
• Host: Mouse
• Conjugation: Alexa-fluor 647
• Applications: FC
• Reactivity: NA
• Formulation: PBS 50% glycerol
• Purification: QMA Hyper D ion exchange chromatography
• Clone: 0
• Concentration: 0.5 mg/ml
• Gene: LAMP3
• Immunogen: human DC-LAMP alkaline phosphatase fusion protein