IMP-1710
IMP-1710
0.01 EUR
Categoria di prodotto: Commercio e industria > Scienza e laboratorio
Fornitore: Gentaur Taglia: 50mg
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- SMILES: O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1c[nH]c2ncc(cc12)C#C
- Formula: C23H19N5O
- Purity: 0.98
- CAS#: 2383117-96-0
- Molecular Weight: 381.439
- Bioactivity: IMP-1710 is an inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1
- IC50= 38 nM in a fluorescence polarization assay) that contains an alkyne moiety for use in click chemistry reactions.1It is selective for UCH-L1 over a panel of 20 deubiquitinating enzymes at 1 μM. IMP-1710 inhibits TGF-β1-induced fibroblast-to-myofibroblast transition (FMT) in primary lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis (IC50= 740 nM). It has been used for labeling UCH-L1 in cell-based assays, followed by click reactions with azide-modified TAMRA and biotin capture reagents.
For research use only.
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National Diagnostics,
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