Monoclonal antibody for 4-Hydroxynonenal

A monoclonal antibody from clone 12F7 against Human 4-Hydroxynonenal. The host species for the production of this antibody is Mouse. The antigen used for immunization is Synthetic 4-Hydroxynonenal modified Keyhole Limpet Hemocyanin (KLH).. The antibody is tested and validated for WB, ICC/IF, ELISA assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:50); ELISA (1:1000). This MAb for 4-Hydroxynonenal is conjugated with ATTO 680.

4-Hydroxy-2-nonenol (4-HNE) is an unsaturated aldehyde derived from lipid peroxidation. 4-HNE is an electrophile and reacts with protein nucleophiles such as cysteine, histine, and lysine (1). Low levels of 4-HNE promote cell survival via cellular antioxidant induction whereas higher levels lead to autophagy, apoptosis, and ultimately necrosis. 4-HNE has been linked to Alzheimer's disease, Parkinson's disease, cancer, cardiovascular diseases, diabetes, and liver disease.

• Shipped on ice packs at +4ºC . Upon receiving the antibody store it at -20ºC.
• The gross weight of the package is 1.4 kg. and the net weight of the product is 0.1 grams.
• The item is not hazardous according to both ADR and UN. Its tariff code is 3002.15.0000 (Immunological products, put up in measured doses or in forms or packings for retail sale). The UNSPSC code of the product is 12352203 (Antibodies).

This product is not for human or animal treatment or consumption. Not for use in diagnostics or therapeutics. For in vitro research use only.