SARS-CoV-2 (COVID-19) Envelope Antibody (HRP)

Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Envelope protein is a small polypeptide that contains at least one alpha-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication (3).

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

• SARS-CoV-2 (COVID-19) Envelope antibody can be stored at 4 ˚
• C for three months and -20 ˚
• C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Research area: Infectious Disease, COVID-19
• Host species: Rabbit
• Species reactivity: Virus
• Homology: Predicted reactivity based on immunogen sequence: SARS-CoV Envelope proteins: (100%)
• Immunogen: Anti-SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope antibody (HRP) (3531) was raised against a peptide corresponding to 10 amino acids near the amino terminus of SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope protein.
• The immunogen is located within the first 50 amino acids of SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope.
• Tested Applications: E, IHC
• Applications: IHC: 2 μ
• g/mL
• Antibody validated: Immunohistochemistry in COVID-19 patient samples. All other applications and species not yet tested.
• Specificity: N/A
• Positive control 1: N/A
• Positive control 2: N/A
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: N/A
• MW explanation: N/A
• Validation: N/A
• Isoforms: SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope has one isoform (75aa).
• Purification: SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: HRP
• Physical state: Liquid
• Buffer: SARS-CoV-2 (COVID-19) Envelope Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: E
• Accession #: QHD43418
• Protein GI #: 1791269092
• NCBI gene ID#: 43740570
• NCBI official full name: envelope protein
• NCBI organism: Wuhan seafood market pneumonia virus
• SWISSPROT #: QHD43418

Optimal dilutions for each application to be determined by the researcher.