Human Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ELISA Kit

This Human Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ELISA Kit employs a two-site sandwich ELISA to quantitate MAP1LC3B.

MAP1LC3b is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.The deduced 125-amino acid protein shares 94% identity with rat Map1lc3. Northern blot analysis detected transcripts of 2.5 and 1.0 kb abundantly expressed in heart, brain, skeletal muscle, and testis, with weaker expression in all other tissues examined. MAP1LC3B was posttranslationally modified. Unlike MAP1LC3A and MAP1LC3C, however, MAP1LC3B did not undergo C-terminal cleavage and did not require the conserved gly120 for posttranslational modification. The essential site for modification of MAP1LC3B was lys124.

Storage: The unopened kit should be stored at 2 - 8°C. After opening, please store refer to protocols.Shipping:Gel pack with blue ice.

• Reactivity: Human
• Sample types: serum, whole blood, plasma and other biological fluids
• Detection range: Please inquire
• Sensitivity: Please inquire Quantitative Sandwich ELISA
• Method of detection: Colorimetric

This kit is intended for research use only. It should not be used for human or animal clinical diagnostics or treatment.