Geldanamycin (Hsp90 inhibitor)

The substance Geldanamycin is a hsp90 inhibitor. It is produced by fermentation and has a purity of >95%. The pure substance is yellow solid which is slightly soluble in methanol, chloroform or DMSO (10 mg/ml); insoluble in water.

• Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1? (3). It is also an inhibitor of pp60src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. It inhibits the transforming activity of abl, erbB, fps, src, and yes (4). Geldanamycin is capable of destabilizing several oncogene and proto-oncogene products
• it is a potent inhibitor of the nuclear hormone receptor family (5). It protects against ?-synuclein toxicity to dopaminergic neurons in Drosophila, and destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines (6). Inhibits basal and hypoxia-induced expression of c-Jun (IC50=75nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase (JNK) activity. Inhibits telomerase activity through inhibition of HSP90, a chaperone required for the assembly and activation of telomerase in human cells (6). It is ~10-fold more potent than herbimycin A. Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.

• The Geldanamycin Hsp90 inhibitor is shipped at ambient temperature. Upon receiving the item keep it at -20ºC. The gross weight of the package is ~0.25 kg and the net weight is 0.005 grams.
• This chemical is classified as non-hzarardous by ADR and UN. Its tariff code is 3822.00.1090 and its UNSPSC code is 41116105

• CAS#: 30562-34-6
• Molecular formula: C29H40N2O9
• Molecular weight: 560.6
• Source: Produced by fermentation
• Purity: >95%
• Solubility: slightly soluble in methanol, chloroform or DMSO (10 mg/ml)
• insoluble in water
• Form: Yellow Solid

This chemical is not intended for human or animal treatment, consumption, diagnostics or therapeutics. It is for research purposes only.