Antibody for Rat HO-1

0.01 EUR

Antibody for Rat HO-1
Antibody for Rat HO-1

Catalog number: / Dimensione: / Prezzo: EUR (IVA esclusa)

Inquiry cart
Indirizzo Email: | Modifica
Dettagli dell'inchiesta
Antibody for Rat HO-1
Antibody for Rat HO-1

Catalog number: / Dimensione: / Prezzo: EUR (IVA esclusa)

Inquiry cart
Disponibilità: Per ordinare Numero di catalogo: SPC-211D-DY350

Fornitore: Gentaur Taglia: 0.1mg

A polyclonal antibody for HO-1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Rat Rat native full-length HO-1 purified from liver tissue. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:400), IHC (1:1000), IP (1:100). This HO-1 antibody is conjugated to Dylight 350.

  • Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin (1). These products have important physiological effects as carbon monoxide is a potent vasodilator
  • biliverdin and bilirubin are potent antioxidants
  • and the free iron increases oxidative stress and regulates the expression of many mRNAs (2). There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3
  • however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals (3). HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation (4). It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency (5), susceptibility to atherosclerotic lesion formation (6), endothelial cell injury, and growth retardation (7). Up-regulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress (4).

  • Shipped on ice packs at +4ºC. Upon receipt keep at -20ºC.
  • The gross weight ( in kg) of the package is ~1.4 kg. The net weight of the product is ~0.1 grams.
  • The item is not hazardous according to both ADR and UN. Its tariff code is 3002.15.0000 (Immunological products, put up in measured doses or in forms or packings for retail sale). The UNSPSC code of the product is 12352203 (Antibodies).

This product is not for human or animal treatment or consumption. Not for use in diagnostics or therapeutics. For in vitro research use only.

0 recensione per Antibody for Rat HO-1

Aggiungi una recensione


☆ ☆ ☆ ☆ ☆  (0)




promozione-kit-citochine-elisa-Kit ELISA Citochine, sconto del 20% - CUSABIO

Acquista due o più kit ELISA per citochine, ottieni uno sconto del 20% – CUSABIO

Stai cercando kit ELISA per citochine di alto livello per far avanzare la tua ricerca? Non guardare oltre. Noi di CUSABIO siamo entusiasti di offrire una promozione esclusiva: acquista due o più kit ELISA per citochine e ottieni uno sconto del 20% sul tuo acquisto! Questa offerta a tempo limitato è progettata per fornire ai...

SuperKine™ West Pico PLUS Chemiluminescent Substrate

Abbkine ha lanciato una promozione per alcuni dei reagenti comunemente utilizzati in laboratorio e attualmente puoi usufruire dei vantaggi paghi uno prendi uno gratuiti per questi articoli. La promozione sarà valida fino al 30 giugno 2024. Non esitate a contattarci per ulteriori informazioni promozionali!SuperKine™ Serum/Protein-Free Cell Freezing MediumSuperKine™ Maximum Sensitivity Cell Counting Kit-8 (CCK-8)SuperKine™ Lipo3.0...

Printgraph – Sistema di documentazione di gel (SDG)

Gel Eye – Sistema di documentazione di gel (SDG) Gel Eye – Sistema di documentazione di Gel (SDG) Vantaggi del sistema Gel Eye: Un software intelligente GelView per scattare e analizzare le foto in tempo reale Meccanismo automatizzato di spegnere la luce UV che contribuisce alla sicurezza dell’utente. Detezione e analisi quantitativi della fluorescenza automatizzati...