17-DMAG (Hsp90 inhibitor)

The substance 17-DMAG is a hsp90 inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is purple solid which is soluble in DMSO (30 mg/ml) and ethanol (10 mg/ml).

17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG.

• The 17-DMAG Hsp90 inhibitor is shipped at ambient temperature. Upon receiving the item keep it at -20ºC. The gross weight of the package is ~0.25 kg and the net weight is 0.001 grams.
• This chemical is classified as non-hzarardous by ADR and UN. Its tariff code is 3822.00.1090 and its UNSPSC code is 41116105

• CAS#: 467214-20-6
• Molecular formula: C32H48N4O8
• Molecular weight: 616.8
• Source: Synthetically produced
• Purity: >98% (TLC)
• NMR conforms
• Solubility: soluble in DMSO (30 mg/ml) and ethanol (10 mg/ml)
• Form: Purple Solid

This chemical is not intended for human or animal treatment, consumption, diagnostics or therapeutics. It is for research purposes only.