Anti-Phospho-CRK-(Y221) antibody
Prodotti relativi
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
- Clonality: Polyclonal
- Host: Rabbit
- Conjugation: Unconjugated
- Applications: WB
- Reactivity: Human,Mouse,Rat
- Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
- Purification: Affinity purification
- Clone: NA
- Concentration: NA
- Gene: CRK
- Immunogen: A synthetic phosphorylated peptide around Y221 of human CRK (NP_058431.2).
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