Anti-IGF-IR antibody
Prodotti relativi
IGF-IR is a protein encoded by the IGF1R gene which is approximately 154,7 kDa. IGF-IR is localised to the cell membrane. It is involved in apoptotic pathways, the GPCR pathway and ERK signalling. It is a receptor tyrosine kinase which mediates actions of insulin-like growth factor 1. The activated protein is involved in cell growth and survival control and is also crucial for tumour transformation and survival of malignant cells. It is formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IGF-IR is expressed in the nervous system, skin, pancreas, lung and muscle. Mutations in the IGF1R gene may result in insulin-like growth factor 1 resistance. STJ93647 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of IGF-IR protein.
- Clonality: Polyclonal
- Host: Rabbit
- Conjugation: Unconjugated
- Applications: WB,IHC,ELISA
- Reactivity: Human,Mouse,Rat
- Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Clone: NA
- Concentration: 1 mg/ml
- Gene: IGF1R
- Immunogen: Synthesized peptide derived from human IGF-IR around the non-phosphorylation site of Y1161.
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