SARS-CoV-2 (COVID-19) Omicron Variant (B.1.1.529) Spike Trimer Recombinant Protein
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Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biologicalprocesses that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Knownreceptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein ofcoronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Mostnotable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike(S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogenand a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells throughinteraction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizingantibodyand T-cell responses, as well as protective immunity.
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week . Store at -20 to -80 °C for twelve months from the date of receipt.
- Tested Applications: N/A
- Applications: Immunogen
- Predicted Molecular Weight: 139.62 kDa
- Physical state: Lyophilized
- Buffer: Supplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5
- Concentration: N/A
- NCBI official symbol: S
- Accession #: UFO069279.1
- Protein GI: N/A
- NCBI gene ID#: 43740578
- NCBI official full name: Surface glycoprotein
- NCBI organism: Severe acute respiratory syndrome coronavirus 2
- Peptide sequence: N/A
- SWISSPROT #: P0DTC1
- Background Reference 1: N/A
- Background Reference 2: N/A
- Background Reference 3: N/A
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: Mammalian cells
- Species: SARS-CoV-2
- By Source: Human Cells
- By Species: Other
- Fusion tag: C-His Tag
- Sequence: The target gene encoding Ser13-Lys1208. Mutation points A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
- Biology activity: N/A
- Purity: >90% as determined by SDS-PAGE
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
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