Nephrin Antibody
Prodotti relativi
Nephrin Antibody: Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm.
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
- Nephrin antibody can be stored at 4˚
- C for three months and -20˚
- C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Research area: Homeostasis
- Host species: Rabbit
- Species reactivity: Human
- Homology: Predicted species reactivity based on immunogen sequence: Mouse: (94%), Rat: (94%)
- Immunogen: Nephrin antibody was raised against a 16 amino acid synthetic peptide from near the center of human Nephrin.
- The immunogen is located within amino acids 870 - 920 of Nephrin.
- Tested Applications: E, IHC-P
- Applications: Nephrin antibody can be used for detection of Nephrin by immunohistochemistry at 5 μ
- g/mL.
- Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
- Specificity: N/A
- Positive control 1: Cat. No. 10-401 - Human Kidney Tissue Slide
- Positive control 2: N/A
- Positive control 3: N/A
- Positive control 4: N/A
- Positive control 5: N/A
- Positive control 6: N/A
- Predicted molecular weight: N/A
- MW explanation: N/A
- Validation: N/A
- Isoforms: N/A
- Purification: Nephrin Antibody is affinity chromatography purified via peptide column.
- Clonality: Polyclonal
- Clone: N/A
- Isotype: IgG
- Conjugate: Unconjugated
- Physical state: Liquid
- Buffer: Nephrin Antibody is supplied in PBS containing 0.02% sodium azide.
- Concentration: 1 mg/mL
- NCBI official symbol: NPHS1
- Accession #: NP_004637
- Protein GI #: 4758822
- NCBI gene ID#: 4868
- NCBI official full name: nephrosis 1, congenital, Finnish type (nephrin)
- NCBI organism: Homo sapiens
- SWISSPROT #: O60500
Optimal dilutions for each application to be determined by the researcher.
0 recensione per Nephrin Antibody