IL-13 Recombinant Protein
Prodotti relativi
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant murine IL-13 is a 12.3 kDa protein consisting of 111 amino acid residues.
The lyophilized IL-13 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IL-13 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing IL-13 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Tested Applications: N/A
- Applications: N/A
- Predicted Molecular Weight: N/A
- Physical state: Lyophilized
- Buffer: N/A
- Concentration: N/A
- NCBI official symbol: Il13
- Accession #: NP_032381.1
- Protein GI: 6680403
- NCBI gene ID#: 16163
- NCBI official full name: interleukin 13
- NCBI organism: Mus musculus
- Peptide sequence: MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F
- SWISSPROT #: P20109
- Background Reference 1: N/A
- Background Reference 2: N/A
- Background Reference 3: N/A
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: E. coli
- Species: Murine
- By Source: E. Coli
- By Species: Mouse
- Fusion tag: N/A
- Sequence: MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F
- Biology activity: The ED50 was determined by the dose - dependent proliferation of TF - 1 cells was < 4.0 ng/mL, corresponding to a specific activity of > 2.5 x 105 units/mg.
- Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
- Endotoxin level is less than 0.1 ng per µg (1EU/µg).
This product is for research use only.
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