DNase II Antibody

171.82 EUR

Disponibilità: In ordine Numero di catalogo: 2059-002mg Fornitore: ProSci Taglia: 0.02 mg

DNase II Antibody: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus. DNase II causes both chromatin condensation and DNA fragmentation. The genes encoding human, porcine, and murine DNase II have been cloned. The DNase II gene encodes a 40 kDa proenzyme. The mature enzyme consists of two non-identical subunits, the 32 kDa (alpha) and 12 kDa (beta) chains, generated by proteolytic processing. Overexpression of DNase II induces chromatin condensation. DNase II is ubiquitously expressed in human tissues.

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

  • DNase II antibody can be stored at 4˚
  • C for three months and -20˚
  • C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

  • Research area: Apoptosis, Signal Transduction
  • Host species: Rabbit
  • Species reactivity: Human
  • Homology: N/A
  • Immunogen: DNase II antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DNase II.
  • The immunogen is located within the last 50 amino acids of DNase II.
  • Tested Applications: E, WB, IHC-P, IF
  • Applications: DNase II antibody can be used for detection of DNase II expression by Western blot at 0.5 μ
  • g/mL. An approximate 40 kDa band can be detected, which represents the pro-enzyme of DNase II. Antibody can also be used for immunohistochemistry starting at 5 μ
  • g/mL. For immunofluorescence start at 5 μ
  • g/mL.
  • Antibody validated: Western Blot in human samples
  • Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
  • Specificity: N/A
  • Positive control 1: Cat. No. 1306 - Human Spleen Tissue Lysate
  • Positive control 2: Cat. No. 1208 - THP-1 Cell Lysate
  • Positive control 3: Cat. No. 10-901 - Human Spleen Tissue Slide
  • Positive control 4: N/A
  • Positive control 5: N/A
  • Positive control 6: N/A
  • Predicted molecular weight: Aprox: 40 kDa
  • MW explanation: N/A
  • Validation: N/A
  • Isoforms: N/A
  • Purification: DNase II Antibody is affinity chromatography purified via peptide column.
  • Clonality: Polyclonal
  • Clone: N/A
  • Isotype: IgG
  • Conjugate: Unconjugated
  • Physical state: Liquid
  • Buffer: DNase II Antibody is supplied in PBS containing 0.02% sodium azide.
  • Concentration: 1 mg/ml
  • NCBI official symbol: DNASE2
  • Accession #: AF047016
  • Protein GI #: 2921838
  • NCBI gene ID#: 1777
  • NCBI official full name: deoxyribonuclease II, lysosomal
  • NCBI organism: Homo sapiens
  • SWISSPROT #: O00115

Optimal dilutions for each application to be determined by the researcher.

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