MeCP2 Antibody

Produkt MeCP2 Antibody

MeCP2 Antibody

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304.00 EUR

MeCP2 Antibody detects endogenous levels of total MeCP2 .
Disponibilità: In ordine Numero di catalogo: AF9265 Fornitore: Affbiotech Taglia: 200ul
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  • Antigen: MeCP2
  • Reactivity: Human,Mouse,Rat
  • Host: Rabbit
  • Clonality: Polyclonal
  • Isotype: IgG
  • Application: WB,ELISA
  • ImmunogenA synthesized peptide derived from human MeCP2 .
  • purificationThe antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
  • FormatLiquid
  • Concentration1mg/ml
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt

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    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms.
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